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A consecutive series of 71 patients diagnosed with HIV-associated dementia (HAD)(1984-1994)were studied to characterize the clinical course of HAD, and to identify predictive markers of rapid neurologic progression. Neurologic progression and survival with HAD is highly variable.A significant proportion of individuals with dementia have prolonged survival of more than 12 months and remain cognitively stable.A history of injection drug use and presentation with prominent psychomotor slowing is associated with more rapid neurologic progression and these patients tend to show more abundant macrophage activation within the CNS. |
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